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Conclusion Parafoveal Müller cells in the Henle fibre layer may guarantee structural stability of the parafovea by increasing retinal compliance and resistance to mechanical stress. In addition, glial cells are of importance in signal processing, cellular metabolism, nervous system development, and the pathophysiology of neurological diseases. The Müller cell of the ver- brate retina provides a splendid example of an accessory cell that exhibits features illustrating every aspect of the complex behavior now associated with glial cells. To dissect the role of Müller cell–derived VEGF in DR and ROP, we recently disrupted Müller cell–derived VEGF conditionally and demonstrated an essential role for Müller cells as a central cellular target to induce retinal inflammation, neovascularization, and vascular leakage and lesion in DR and ROP-like diseases (8,9). Müller cells subserve many of the metabolic, ionic, and extracellular buffering requirements of neurons . Although much is yet to be learned about the functions of Müller cells in the retina, it is clear that they play important roles in retinal development, in the preservation of its integrity and in maintaining neuronal survival [4–6]. Thus, Müller cells constitute an anatomical link between the retinal neurons and the compartments to exchange molecules.

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Research output: Contribution to journal › Journal article › Research › peer-review Microglia and Müller cells are cell types that feature prominently in responses to disease and injury in the retina. However, their mutual interactions have not been investigated in detail. Here, we review evidence that indicate that these two cell populations exchange functionally significant signals under uninjured conditions and during retinal inflammation. The CELL function returns information about the formatting, location, or contents of a cell. For example, if you want to verify that a cell contains a numeric value instead of text before you perform a calculation on it, you can use the following formula: =IF(CELL("type",A1)="v",A1*2,0) För att en T-cell ska känna igen ett antigen krävs en antigenpresenterande cell (APC).

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It performs many of the functions subserved by astrocytes, oligodendrocytes and ependymal cells in other regions of the CNS. Müller cells, the major type of glial cells in the retina, are responsible for the homeostatic and metabolic support of retinal neurons. By mediating transcellular ion, water, and bicarbonate transport, Müller cells control the composition of the extracellular space fluid.

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In their stead, the Müller cell serves as the principal glial cell of the retina. It performs many of the functions subserved by astrocytes, oligodendrocytes and ependymal cells in other regions of the CNS. Müller cells, the major type of glial cells in the retina, are responsible for the homeostatic and metabolic support of retinal neurons. By mediating transcellular ion, water, and bicarbonate transport, Müller cells control the composition of the extracellular space fluid. Müller cells, the major type of glial cells in the retina, are responsible for the homeostatic and metabolic support of retinal neurons. By mediating transcellular ion, water, and bicarbonate In combination, our single-cell experiments, the theoretical considerations, and the transmission and reflection measurements strongly suggest that Müller cells are, and function as, optical fibers in the retina, relaying light from the inner surface to the layer of the photoreceptors while bypassing scattering structures present.

Muller cells function

It performs many of the functions subserved by astrocytes, oligodendrocytes and ependymal cells in other regions of the CNS. Müller cells, the major type of glial cells in the retina, are responsible for the homeostatic and metabolic support of retinal neurons. By mediating transcellular ion, water, and bicarbonate transport, Müller cells control the composition of the extracellular space fluid. Müller glial cells are a major cellular component of the retina and engage in numerous roles vital to retinal function, such as structural, nutritional, homeostatic, osmotic, metabolic, and growth In combination, our single-cell experiments, the theoretical considerations, and the transmission and reflection measurements strongly suggest that Müller cells are, and function as, optical fibers in the retina, relaying light from the inner surface to the layer of the photoreceptors while bypassing scattering structures present.
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3 Total cholesterol  Müllerceller — Gliaceller är en grupp av olika celltyper i nervsystemet.

Among multiple functions, Müller cells are responsible for the removal of neurotransmitters, buffering potassium, and providing neurons with essential metabolites. In their stead, the Müller cell serves as the principal glial cell of the retina. It performs many of the functions subserved by astrocytes, oligodendrocytes and ependymal cells in other regions of the CNS. Müller cells, the major type of glial cells in the retina, are responsible for the homeostatic and metabolic support of retinal neurons.
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In vivo Activation of Wnt Signaling Pathway Enhances

av M Bouwens · 2009 · Citerat av 342 — fatty acids can have beneficial effects on human immune cells, such as peripheral blood mononuclear cells (PBMCs). Michael Müller,. av HY Yhim · 2017 · Citerat av 2 — CD11b+CX3CR1+ cells were analyzed by flow cytometry using peripheral blood by IL-10 [15, 20], suggesting that CD11b+CX3CR1+ cells function as MDSCs. Delabie J, Ott G, Muller-Hermelink HK, Campo E, Braziel RM, Jaffe ES, Pan Z,  Biological process, Molecular function, Disease Mucus-secreting cells, Muller glia cells, Pancreatic endocrine cells, Paneth cells, Peritubular cells, Proximal  ERK5 functionally links ALK signaling to MYCN expression in Goldring, J. Müller, M. J. Cross, ERK5: Structure, regulation and function.


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The purity of the Müller cell cultures was characterized after each passage by testing for the expression of vimentin, AQP-4, GS, and CRALBP (Bunt-Milam and Saari, 1983). Müller cell CM was generated by culturing confluent wild-type or sEH −/− Müller cells for 48 h. Many different types of cancer show a high incidence of TP53 mutations, leading to the expression of mutant p53 proteins. There is growing evidence that these mutant p53s have both lost wild-type p53 tumor suppressor activity and gained functions that help to contribute to malignant progression. Understanding the functions of mutant p53 will help in the development of new therapeutic How do you say Muller cells?